Morus alba meyve ekstresinin biyokimyasal özelliklerinin ve egzamalı hastalarda iyileştirici etkisinin değerlendirilmesi

Eczema is considered one of the chronic diseases spread globally. In this study, the ointment was prepared from the white mulberry plant (Morus alba), which contains vitamin E. 200g of dried mulberry, grind and extracted with 96% ethanol, 60oC in reflux setup, filtered in whatmann filter paper and evaporated with rotovap, using separation funnel suppled with butanol, after acquiring two phases, butanol phase was evaporated to obtain dried extract. Biochemical content of the extract was evaluated via gas chromatography analysis. Water-in-oil (W/O) emulsification was used to prepare ointment that contains 0.5g extract for each individual. The number of individuals on whom the ointment was tested were 110 divided into 3 groups (group one with eczema, group two healthy and group three control) with different ages and genders to compare the results for a period ranging from 4 to 6 weeks. For each group, blood sample were collected to be analyzed (Vitamin E, Granzyme B and Lipid profile). The antibacterial activity of the extract was tested against S. aureus. at different concentrations which was detected on the skin surface of eczema patients. The results indicate that 0.5% of the extract was effective on eczema patients with slight changes in the blood analysis results, vitamin E were enhance from 3.776 µg/ml to 5.681 µg/ml, granzyme B were significantly lowered from 180.06 pg/ml to 141.09pg/ml and lipid profile slightly changed in patients. The antibacterial activity of the extract against S. aureus was recorded and different inhibition zones were observed (9mm to 16mm). This study shows that mulberry abstract can be used effectively as a supplement for eczema treatment.