Neutrophil/lymphocyte ratio, platelet/lymphocyte ratio, and mean platelet volume as potential biomarkers for early detection and monitoring of colorectal adenocarcinoma

Colorectal carsinoma (CRC) is the most common cancer diagnosed in the gastrointestinal system and it's second among all deaths due to cancer in the world after lung cancer. In this study, we are aim to investigate the availability of neutrophil/ lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), mean platelet volume (MPV) of the CRC early diagnosis and postoperative recurrence monitoring in patients with diagnosed CRC as biomarkers. 1020 patients with diagnosed CRC files between 2005-2015 in Dokuz Eylül University Faculty of Medicine were screened. 188 patients of in the early stages with Providing appropriate conditions for study and accessible data; demographic, laboratory and histological data were recorded. Before tumor resection in our group of patients included in the study assessment NLR mean 3.15 ± 2.6, PL: 163.05 ± 84.07, MPV mean: 8.19 ± 1.17 fl were measured. In this study, patients were divided into 2 groups recurrent positive and recurrent negative. In 25 patients (13.3%) recurrence was observed. Before the tumor resection NLR was higher in recurrent positive group than recurrent negative group. In recurrent negative group were observed in a significant decrease in MPV after tumor resection and in recurrent positive group NLR, PLR or MPV didn't significantly reduce after tumor resection. In recurrent positive group; NLR, PLR and MPV didn't significantly increase on time recurrence when resection of the primary tumor follow-up. According to the assessment disease stage, the higher MPV values in stage 3 than stage 2 were statistically significant. As a result this study shows NLR, PLR MPV could be used as a prognostic factor for screening and follow up prognostic tumor resection in CRC. Key words: colorectal cancer, mean platelet volume, platelet / lymphocyte ratio, neutrophil / lymphocyte ratio, biomarker