The effect of high intensity interval training on inflammation and oxidative stress markers in obese adolescents

Objective: Evaluation of the effect of 12-week high intensity interval training (HIIT) on body composition, blood lipids, adipose tissue hormones, metabolic, inflammation and oxidative stress markers in obese adolescents. Methods: Obese (age: 15.28 ± 2.93 years, BMI: 33.21 ± 4.98 kg / m2, A = 16; K = 16 ) 32 volunteer adolescents anthropometric (height, body weight, waist and hip circumference, waist / hip ratio) and body compositions (Tanita SC 330MA) were determined, blood samples were analyzed (Thermo Scientific Multiskan FC, 2011-06, USA, ELISA-Thermo Scientific, USA). The HIIT group and the control group were subjected to health checks by resting ECG and blood pressure. The training group started after 3 weeks of pre-adaptation studies (30 min 40-45 Rpm, Matrix U3X stationary bike). The participants in the HIIT group participated in a 12-week stationary bike HIIT workout for 3 days a week involving 30 sec of work and 60 sec of resting intervals with 90-95% of the maximum heart rate reserve (HRR max) (1st, 2nd, 3rd, 4th week /3 repeats-12 min; 5th, 6th, 7th, 8th /4 repeats-14 min; 9, 10, 11, 12. week /5 repeats-16 min). The intensity of the exercises was monitored with pulse meter (Polar M400). During this period, the control group did not participate in an exercise program. Results: According to the results of the GLMM model applied in the study, in the insulin parameter of the interaction of group, age and time; waist and hip circumference of the group and time interaction, all metabolic ((insulin (U / L), glucose (mg / dl), HOMA-IR, total cholesterol (mg / dl), LDL (mg / dl) / dl), triglyceride (mg / dl), adiponectin (µg / ml), leptin (ng / ml) and all inflammation parameters (hsCRP (mg / dl), TNF- α (pg / ml), IL-6 (pg / ml), and AGE (RFU), one of the pro-oxidant parameters, was determined to be statistically significant (p <0.05). The effect of group and gender interaction on body fat percentage and total body water percentage parameters was significant (p <0.05), among the parameters, ROS (RFU), TBARS (nmol/mL) parameters were not significant (p>0.05). There was no group, time, age and gender interaction in all antioxidant parameters (FRAP, SOD, GSHPX) (P <0.05). Conclusions: The 12-week HIIT program applied in obese adolescents has positive effects on metabolic parameters, blood lipids, oxidative stress markers, and inflammation. Keywords: Obesity, adolescent, high intensity interval training, inflammation, oxidative stress.