Examination of Angiopoietin-like proetin-4, Neuropeptide Y, Omentin-1 levels of Obese and Nonobese patients with Polycystic Ovary Syndrome

The pathogenesis of PCOS and obesity is not clarified yet. But some parameters such as NPY, and Angptl-4 ,Omentin-1 are thought to be involved in this pathogenesis. In this study, we aimed to show possible effect of these parameters.17 obese, 32 non-obese patients with PCOS and 20 healthy subjects were included in this study. The control group consisted of was constituted from healthy patients, who had and having no PCOS or DM history. PCOS and obesity were diagnosed in Kırıkkale University Faculty of Medicine. The demografic parameters of all patients were analyzed at Biochemistry Laboratory of Kırıkkale University Faculty of Medicine. Levels of serum NPY, Omentin-1, Angptl-4 were measured at Gazi University School of Medicine, Department of Medical Biochemistry.Patients were divided into three groups. Group I was consisted of 20 healthy volunteers, 32 non-obese women with PCOS was named as group II and group III was consisted of 17 obese women with PCOS. Serum NPY , Angptl-4, free testosterone, total testosterone, , LH, SHBG, estradiol, DHEA-SO4, androstenedione, TG and LDL-C levels and HOMA-IR, Ferriman-Galwey scores were significantly higher in group II when compared group I and similarly in group III comparing with group II (p<0,005). When comparing all PCOS patients (obese + non-obese) with healthy volunteers; Omentin-1 and HDL-C levels were significantly low in PCOS group (p<0,005). In obese PCOS patients NPY, Angptl-4, HOMA-IR, BMI, and waist circumference levels were significantly higher, while Omentin-1 levels lower than those in non-obese PCOS patients (p <0.005 for both of them).As a result of this study, both in the obese and non-obese PCOS patients, there was a significant increase in levels of NPY and Angptl-4 and a significant decline in the anorexigenic peptide, Omentin-1 when compared to healthy subjects.In conclusion, insulin resistance in PCOS patients may be related to the differences of NPY, Angptl-4 and omentin-1 levels and the effects of these differences on metabolic pathways.Key Words; Policystic Ovary Syndrome, Obesity, Angiopoietin-like protein 4, Neuropeptide Y, Omentin-1