Relation between DIO2, PPAR, PDE8B gene polymorphisms with prediabetes, metabolic parameters and thyroid functions in obesity

Whether many genetic disorders hold to account for obesity and related disorders, the etiology is multifactorial. DIO2 (Deiodinase Type 2) plays role in regulation of thyroid function, PPAR? (Peroxisome proliferator-activated receptor ?) plays role in insulin resistance, PDE8B (Phosphodiesterase 8B) plays role in cAMP (cyclic adenosin monophosphate) metabolism. We aim to evaluate the roles of DIO2, PPAR? and PDE8B gene polymorphisms in obesity and obesity related disorders.Prediabetic-obese patients (n=49), normoglycemic-obese patients (n=54), normal weight-normoglycemic participants (n=51) who applied to Gaziantep University Hospital Department of Endocrinology and Metabolism Department, were enrolled to study. Anthropometric measurements and biochemical studies were done for all the participants. DNA samples collected from blood samples of all the participants were analysed with PCR-RFLP method for DIO2 Threonin92Alanin, PPAR? Prolin12Alanin, PDE8B rs4704397 gene polymorphisms.DIO2 Thr92 genotype was significantly higher in normal weight-normoglycemic participants (p=0,001). But metabolic parameters were not influenced (p>0,05). PPAR? Pro12 or Ala12 genotype did not influence obesity and metabolic parameters(p>0,05). A allele in PDE8B rs4704397 position was seen more frequent in prediabetic-obese patients than normoglycemic-obese patients (p=0,003).As a result, we thought that among genetic disoders; DIO2 and PDE8B polymorphisms which have an effect upon thyroid functions, responsible for prediabetes development in obesity. We think further studies are neccessary to evaluate this hypothesis.