Investigation of amounts oxide and reducte glutathione and relationship between glutathione reductase and peroxidase
2011
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Advisor: Prof. Dr. Fikret Karataş
Abstract (EN)
In this study, erythrocyte glutathione peroxidase (GSH-Px) and glutathione reductase (GSH-Rd) enzymes activity of 60 people diagnosed with type 2 diabetes and 21 healthy persons as control group were determined using UV-spectrophotometer and erythrocyte oxidized glutathione (GSSG) and reduced glutathione (GSH) amounts were determined by high performance liquid chromatography (HPLC).While GSSG amounts of people diagnosed with Type 2 diabetes were higher than control group, amounts of GSH were found to be lower than the control group (p<0.005).In the same way, both GSH-Px and GSH-Rd activities in erythcrocytes of type 2 diabetes were found to be lower than the control group (p<0.005).In conclusion, it can be said that, increase of GSSG amount, GSH-Px and GSH-Rd activities with decrease of GSH amount of type 2 diabetics can be expressed by oxidative stress.Keywords: GSH, GSSG, GSH-Px, GSH-Rd, Type 2 diabetes
Author
Ayşe Birişik
How to Cite
Ayşe Birişik (Master Thesis). Investigation of amounts oxide and reducte glutathione and relationship between glutathione reductase and peroxidase, 2011, Fırat University.
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