The relation between apoptotic activity and proliferative activity and metastasis in surface epithelial tumors of ovary

Tumours of the ovary represent about %30 of all cancers of the female genital system. Ovarian cancers are sixth most common cause of death due to cancer in women. During the diagnosis % 75 of the tumours spread out of the pelvis. In our study, apoptotic and proliferative activity were investigated by using M30, Ki-67, CD44 in the benign, borderline and malign ovarian surface epithelial tumours. We aimed to detect the association between these markers, lymph node status, metastasis and prognosis.Sixty ovarian surface epithelial tumours (20 bening, 20 borderline and 20 malign) were obtained from archives of the Fırat Universty Pathology Department. Association between the immunostaining of these markers and lymph nodes invasion and distant metastasis were researched.Prolifaration index of Ki- 67 was lowest in bening group and the highest in malign group. There was a statistically significant difference between the groups. CD44 in bening group was lower than borderline and malign groups. This difference was statistically significant. Staining of M30 intensity were not significant as statistically but percentage of M30 staining significantly higher in bening group than borderline and malign groups. There was no association between markers, lymph nodes involvement and metastasis in malign group.As a result in the ovarian surface epithelial tumors Ki- 67 and CD44 positivity increases with malign potential. But there is a reverse association with M30. There was no association between these markers and lymph nodes invasion and distant metastasis which affect prognosis.