Association of impulse control disorder with GRIN2B gene polymorphisims in Parkinson's patients

Title: Association of impulse control disorder with GRIN2B gene polymorphisims in Parkinson disease Aim: Parkinson's disease (PD) is a progressive neurodegenerative disease that results from the death of dopaminergic neurons in the substantia nigra (SN) pars compacta. Impulse Control Disorder (ICD) and related behaviors are characterized by an inability to resist the urge to perform a self-rewarding action that will cause long-term harm. Not all patients with PD who are treated develop ICD, suggesting that there may be a genetic predisposition in genes involved in some neurotransmitter pathways. In the literature, some genetic factors thought to have a role in the development of ICD in Parkinson's cases have been described in studies carried out so far. In our study, it was planned to investigate the effect of GRIN2B gene rs1806201 and rs7301328 polymorphisms on the development of ICD in patients with PD. Method: In our study, DNA isolation was performed in blood samples taken from 140 Parkinson's patients (70 with and 70 without ICD) and 50 control individuals to investigate the relationship of GRIN2B gene polymorphisms with the development of Parkinson's disease and impulse control disorder in Parkinson's disease. In our study, GRIN2B rs1806201 and rs7301328 polymorphisms were determined using TaqMan SNP and RFLP methods in peripheral blood samples taken from 140 Parkinson's patients with 70 DBP and 70 without ICD, and 50 control subjects. Results: In our study, no statistically significant difference was observed between the patients and controls on the genotype, allele frequency distribution (p=0.296 and p=0.108, p=0.272 and p=0.323, respectively) and ICD development of the rs1806201 and rs7301328 polymorphisms (p=0.790, p=0.456, respectively). Conclusion: As a result of our study, no significant difference was found between GRIN2B rs1806201 and rs7301328 polymorphisms and the development of Parkinson's disease and impulse control disorder. However, our study data need to be supported by studies to be conducted in large patient cohorts in the Turkish population. Keywords: Parkinson's Disease, Impulse Control Disorder, GRIN2B