The comparison of brain volumes of parkinson and parkinson plus patients

In this study, we aimed to find the volumetric difference between the brain volumes of individuals diagnosed with Parkinson's Disease (PD) and Parkinson plus disease (PPD) by comparing them with the brain volumes of healthy individuals. In the study 25 individuals diagnosed with PH, 25 individuals diagnosed with PPH, 25 healthy individuals were included in the study. İt was determined that in our study, compared to PPD and PD, there was a decrease in putamen volume (p=0.03635) and an increase in percentage value of corpus amygdaloideum volume asymmetry (p=0.03946). Between the PD and control groups, it was found that there was an increase in nucleus caudatus volumes and percentage value of globus pallidus volume asymmetry (p<0.001, p<0.001). Other parameters did not show any statistically significant difference. In the right/left side evaluation, the alteration in the volume of the right/left corpus amygdaloideum and right/left nucleus accumbens in PPD was statistically significant, while this difference was not significant in the PD and control group. In addition, in the PD group, there is a statistically significant difference in the right/left lateral ventricular volume. As a result of our study, we concluded that determining the percentage value of globus pallidus volume asymmetry and nucleus caudatus volumes is important in the diagnosis of PD and PPD, and determining the putamen and percentage value of corpus amygdaloideum volume asymmetry is of critical importance in the differential diagnosis of PPD from PD.