Comparison of gingival crevicular levels of BPİ and i̇nterleukin 1-beta at individuals with periodontal disease and HEALTHY

Objective: The aim of our study is to determine the amounts of BPI (Bactericidal permeability protein) and interleukin-1beta (IL-1β) in gingival fluid samples obtained from individuals with periodontally healthy and periodontal disease, to compare these amounts between study groups, and to evaluate their relationship with clinical parameters. Method: Systemically healthy and non-smoking individuals were included in the study. The study groups included a total of 100 individuals, 50 of whom were periodontally healthy (healthy group) and 50 with periodontal disease (periodontitis group). The clinical parameters of plaque index (PI), gingival index (GI), pocket depth (PD), clinical attachment level (CAL), and bleeding on probing (BOP) were measured. The gingival fluid samples were taken in the direction of the paper strip and ELISA method was used for their analysis. Results: A positive statistically significant relationship was found between IL-1β levels and all clinical parameters (PI, GI, PD, CAL, BOP) (p<0,01). Likewise, there is a positive significant relationship between BPI levels and clinical parameters (p<0,01). There is a statistically significant positive correlation between GCF volume and clinical parameters PI (r: 0,722), GI (r: 0,740), PD (r: 0,742), CAL (r: 0,751) and BOP (r: 0.752) (p < 0,01). In the comparison between the groups, it is seen that both IL-1β and BPI levels were statistically significantly higher in the periodontitis group compared to the healthy group (p < 0,001). Conclusion: In cases where clinical parameters increase, IL-1β amounts also increase significantly. The amount of IL-1β in individuals with periodontal disease is significantly higher compared to healthy individuals. There is positive correlation between BPI and clinical parameters. The amount of BPI in individuals with periodontal disease is significantly higher than in healthy individuals. More studies are needed to better understand the importance and therapeutic effect of BPI in periodontitis.