The evaluation of the efficacy of PRP (Platelet-Rich Plasma) in treatment of periodontal i̇ntrabony defects

In recent studies it is pointed out that ? Platelet-Rich Plasma? (PRP), may have potential to stimulate regeneration and accelerate the healing process of the wound. The researches about PRP are concentrated on the use of grafts like deproteinized bovine bone (Bio-Oss) in combination with PRP in dentistry.RANKL-receptor activator of NF-?B ligand, IL-17, IL-1ß and osteoprotegerin-OPG are essential cytokine for osteoclastogenesis and important in the pathogenesis of human metabolic bone diseases.The aim of this study was to evaluate the efficiency of PRP clinically , radiographically and immunologically in the intrabony defects when it was used with Bio-Oss which OPG/RANKL, IL-1ß and IL-17 levels of gingival crevicular fluid were collected and analyzed by the end of 3 and 6 months of healing periods.30 defects of 15 patients with periodontitis were treated with Bio-Oss or Bio-Oss and PRP . The clinical, radiographic and immunological evaluation were obtained and recorded before and 3-6 months after the treatment. The changes were tested statistically with independent t test and paired t test.After the treatment clinical and radiographical measurements improved in both groups, GCF OPG levels increased and IL-17, IL-1ß levels decreased in both groups. However better improvements were recorded in test group, it was not statistically significant.These results suggest that periodontal treament with PRP/graft seems to be more effective than graft only in terms of GCF bone markers like OPG, IL-17 and IL-1ß but it is not statistically significant.