SYNTHESIS OF PYRIMIDINE CONDENSED THIAZOLE COMPOUNDS ANDINVESTIGATION OF IN VITRO ANTI CANCER ACTIVITY

In this study, new thiazole derivatives were synthesized from pyrimidine derivatives, which are widely used in the pharmaceutical industry and medicine in the fight against various diseases such as cancer. In the first stage of the study, 5-benzoyl-4,6-diphenyl-1,2,3,4-tetrahydro-2-thioxopyrimidine derivatives were successfully obtained. In the second phase, these pyrimidine derivatives were reacted with propargyl bromide in the presence of potassium carbonate catalyst to synthesize new thiazole compounds condensed with the pyrimidines synthesized in the first phase. All compounds obtained were structurally characterized using ¹H-NMR, ¹³C-NMR, LC-MS, and IR spectroscopy methods. Additionally, the MTT assay was applied to evaluate the cytotoxic effects of the synthesized thiazole derivatives. As a result of the tests, the compounds exhibiting the least cytotoxic effect on the healthy cell line were identified. It was observed that these selected compounds provided high inhibition rates ranging from 59% to 80% in the brain cancer cell line (U87MG).