Investigation of TRPM2 activity in placental invasion anomaly

Placenta accreta spectrum, which encompasses abnormal placental invasions including accreta, increta, and percreta, represents serious pregnancy-related complications that can lead to significant mortality and morbidity. This study aimed to investigate the immunohistochemical expression of TRPM2, which is known to be activated by oxidative stress. A total of 44 women diagnosed with PAS and 16 healthy women were included in the study, forming two groups: the patient group and the control group. Routine paraffin embedding was performed, and sections were taken from the placentas to apply immunohistochemical staining techniques for TRPM2, VEGF, and MMP9. The samples were then examined under light microscopy, and statistical analyses were conducted. In the study, a statistically significant increase in the immunoreactivity of TRPM2, VEGF, and MMP9 was observed in the PAS group compared to the control group.