The prognostic value of brain natriuretic peptid in patients undergoing to coronary artery bypass surgery

THE PROGNOSTIC VALUE OF BRAIN NATRIURETIC PEPTID İN PATIENTS UNDERGOING TO CORONARY ARTERY BYPASS SURGERYABSTRACTBrain natriuretic peptid (BNP) is a ventricular hormone that is sensitive and specific marker of changes in ventricular function .It is sample screening test for symptomless left ventricular failure.The aim of this study was examine there is a corelation between the preoperative plasma level of BNP and early morbidity in patients undergoing to coronary artery bypass.During the 11month period,we retrospectively evaluated 22 consecutive patients who was operated on for coronary artery bypass. Patients had not have other system and cardiac disease and had not EF ? 50.Preoperative plasma BNP values was statisticaly compired with early postoperative morbidity findings.BNP analysis was made by `Electrohemoluminescent immunassay method and Roche Diagnostic Indianapolis, Indiana proBNP Elecsys 1010 autoanalyzer with tecnique and ?125 pg/ml was accepted sign for cardiac function disorder. Postoperative morbidity criterias were accepted as;staying longer than 4 day in intensive care unit and longer than 10 days in hospital, mechanic ventilatory support longer than 48 hours, necessity for inotrops or IABP(ıntra aortic baloon pump) support.All analysies were done by using SPSS 9.0 statistical software pocket. One or more of above criterias for morbidity are established in 12 of 22(%54) patients.There were no significant differance for demografic findings between the patients who morbidity were established and was not. Preoperative plasma BNP level was 763±53 pg/ml in 12 patients with morbidity while 113±47pg/ml among 10 patients with no morbidity.(P<0.05)With the results it is concluded that preoperative plasma BNP levels is a reliable indicator for early postoperative morbidity in patients undergoing coronary artery bypass.KEY WORDS: Cardiopulmonarybypass, BNP(Brain Natriuratic Peptid), postoperative morbidity