Evaluation of serum sirtuin and adiponectin levels in patients with primary open-angle glaucoma and exfoliative glaucoma

The aim of this study is to compare the serum sirtuin 1 (SIRT1) and adiponectin levels in patients with primary open-angle glaucoma (POAG) and exfoliative glaucoma (EG) with healthy control subjects over 50 years of age. Blood samples were collected from 40 patients with POAG, 38 patients with EG and 40 individuals over 50 years of age with no systemic or ocular disease. Serum SIRT1 and adiponectin was estimated by Enzyme Linked Immunosorbent Assay (ELISA). In patients with POAG (0.731 ng / ml), a significant (p = 0.004) decrease in SIRT1 concentration was observed compared to controls (1.423 ng / ml). Statistically significant difference was not found in patients with EG (1.155 ng / ml) compared to controls and patients with POAG (p=0,345, p=0,325). There was no statistically significant difference in serum adiponectin levels between the 3 groups (p=0.590). There was no statistically significant difference found to the distribution of SIRT1 levels by sex (p=0.343). Serum adiponectin levels were significantly (p=0.002) higher in women. In conclusion; in this study, serum SIRT1 level was found to be lower in patients with POAG than control subjects. There was no statistically significant difference in adiponectin levels between the 3 groups. Our results suggest that SIRT1 may play a protective role in POAG. Key words: Primary open angle glaucoma, exfoliative glaucoma, sirtuin, adiponectin, neurodegeneration