Evaluation of health related qaulity of life in patients with primary biliary cholangitis

Aim: To asses the health related qaulity of life (HRQOL) in patients diagnosed with primary biliary cholangitis(PBC). Methods: A single-centered, prospective , cross-sectional study was conducted among patients diagnosed with primary biliary cholangitis in the Gastroenterology out-patient clinic at Gazi University Hospital, Ankara. Data was collected using a sociodemographic information form, hospital medical database and a PBC-40 questionnaire. Statistical comparison analysis was performed using Chi-square test for categorical variables and Mann-Whitney U test for continous variables. P values less than 0.05 were considered significant. Results: A total of 37 PBC patients were included in the study. The mean age of the participants was 54.2 ± 8.6. When evaluating the PBC-40 questionnaire scores from each domain in terms of severity, we found that majority of patients in itch %40.4 (n=19) and social %42,6 (n=20) domains had mild severity, as for fatigue %42.6 (n=20), cognitive %36 (n=17), emotional %40.4 (n=19) and other symptoms %44.7 ((n=21) domains had moderate severity. A statistically significant difference was found between AMA positive and AMA negative patient groups in the itch domain (p=0.007). Discussion: With this study on a Turkish based population using the PBC-40 questionnaire we were able to demonstrate that patients with PBC had a significantly impaired HRQOL and fatigue was the most seen symptom.