Investigation of the activities of prolidase in the patients with psoriasis

Objective: In the present study, we aimed to indicate the potent role of prolidase activity, representing the metabolism of collagen proteins, in psoriasis, therefore we investigated the serum prolidase activity of the patients with psoriasis and the healthy group. Also, whether there is a relationship between prolidase activity and complete blood cell count parameters has been investigated. Sharply-circumscribed and ingrained in erythematous plaques or papules, psoriasis is considered as a remitting skin disease whose etiology is regulated by genetic and immunologic mechanisms. Material and Method: In this study, we included 40 patients whom clinically diagnosed as chronic moderate and severe plaque type psoriasis among the patients applied to Gaziantep University Medical Faculty Research and Practice Hospital and; and 50 healthy people with any systemic disease and don't use alcohol, cigarette and medication. Within the scope of the study, the serum prolidase levels of the participants were investigated by Chinard method. Result: According to the findings, serum prolidase level of the patients was determined to notably increase compared with the control group (t=8,075; p<0,0001). Upon assessing whether there is a relationship between prolidase activity and complete blood count parameters, a weak positive correlation was found. High rate of Lymphocyte was thought to explain this correlation (r=0,105; p<0,0001). Conclusion: The prolidase activity of the patients was determined to be inversely correlated with lymphocyte rate, which points to a relationship between prolidase activity level and tissue destruction. Having already been performed, the studies are supportive of our results. New studies in this field will become more of an issue to lighten the pathogenesis of psoriasis.