Püskürtmeli kurutucu ile biyokompozitlerin hazırlanması ve ilaç taşınım sistemlerinde kullanımı

Biodegradable and biocompatible polymers have been widely used in drug delivery systems with an increasing interest. The main reason to drive biopolymers for top material for drug delivery applications is after drug depletion, the carrier degraded in the body to form products that are easily resorbed or eliminated. On the other hand, the unwanted adverse effects have to be minimized and therapeutic improvement has to be maximized at the same time for an effective and useful drug delivery tool. The only way to obtain improved therapy is that creating very effective drug release in the body and bio-based polymers could provide these vital necessities. Because of these reasons, biopolymers are preferred for drug delivery systems. The biodegradable polymers are a new class of controlled release polymers developed for the interstitial delivery of drugs to their target site in human body over periods ranging from days to years. These polymers can release molecules of any size in a predictable fashion. Their degradation products are non-cytotoxic and biocompatible. The only way to obtain improved therapy is that creating very effective drug release in the body and bio-based polymers could provide these vital necessities. Because of these reasons, biopolymers are preferred for drug delivery systems. Controlled drug delivery systems have become increasingly attractive options for inhalation therapies. A large number of carrier systems have been developed and investigated as potential controlled drug delivery formulations to the lung, including drug loaded lipid and polymer based particles. However, there are some extraordinary specifications should have for a drug delivery material. First of all, polymers which are used in a drug delivery system, it has to be biodegradable and biocompatible. For example, polycaprolactone, polyethylene glycol , polylactic acid, chitosan, chitin, and polyglycolic acid and their blends or copolymers are widely used for drug delivery systems because of controllable particle diameter, particle size distribution, and biodegradation rate in human body. Spray drying is transformation of material from solution state to powder form by spraying feed into a hot air medium. The production of dried particles from a liquid feed in a single processing step makes spray drying a unique and important process. Since then, a tremendous development of the spray drying process with the refinement in the hardware and equipment configuration and improved understanding of fluid dynamics has made it versatile technique operational in diverse industrial fields. Spray drying is widely used for the drying of heat-sensitive foods, pharmaceuticals, and other substances mainly due to rapid solvent evaporation and homogeneous particle size distribution. At last decade, spray dryers have been preferred for pharmaceutical industry by combining drug delivery systems with micro-particle uniform distributed polymeric materials. Furthermore, amorphous solid dispersions, soluble complexes, encapsulated systems, solid self-emulsifying systems and nano-dispersions of poorly soluble drugs prepared by spray drying are primary solubilization strategies. The present work concerns the preparation and characterizations of biodegradable, biocompatible biopolymer based composites and obtain uniform particle size distribution at the same time. For achieving of the goal our study, we used polycaprolactone, polyethylene glycol, chitosan, casein, and sodium alginate to prepare drug delivery system and spray dryer will be our tool to obtain microspheres. Triple mixture of the polymers are used such as polycaprolactone-polyethylene glycol-chitosan, polycaprolactone-polyethylene glycol-casein, and polycaprolactone-polyethylene glycol-sodium alginate. First of all, we are evaluated effects of spray drying conditions and composition of the microencapsulating formulation. Secondly, the most uniform distributed particle size microsphere are selected and drug active ingredient is loaded to it. L-ascorbic acid is an active ingredient for the study. After that, drug encapsulation and drug release studies are performed. Drug release experiments are maintained at different pH solutions (pH 2.5, 7.4, and 9.6). Finally, drug release kinetics are determined by widely used equations to describe the degradation kinetics; Zero-order, First-order, Higuchi, Hixson-Crowell, and Korsmeyer-Peppas. Furthermore, L-ascorbic acid release mechanism from microspheres is also determined. Release profiles of three microspheres produced are obeyed to previously developed kinetic models to perform possible release mechanisms; The Korsmeyer–Peppas model is the best described each release scenario. Encapsulation and drug release ratio are easily adjusted by changing structure of microspheres. Particularly, release behavior of microspheres are changed by replacing biopolymers in the drug structure. By this way, released L-ascorbic acid ratio in different release mediums are adjusted. The main reason of using of ternary polymer mixture is that to obtain best performance from a drug material because these polymer has some superior features but they are not enough separately. The importance of the study is producing of a stable and effective drug encapsulation system using ternary polymer mixture by spray dryer Our study is proposed as an alternative or adjuvants for controlling release of L-ascorbic acid. By this way, we can achieved higher drug loading and drug release efficiency in our study.