Investigation of the effect of sevoflurane administeration during day and night period on melatonin levels in rats

Aim: The aim of this study is to investigate the effects of night-day on melatonin level under sevoflurane administration in rats.Material and Methods: 15 days old 24 rats were included and divided into 4 groups by randomisation. 2,6 % sevoflurane 6 L?min-1 of oxygen was administered to rats between 07:00 pm-01:00 am (night group) and 07:00 am-01:00 pm (day group) in spring and 6 L?min-1 of oxygen was administered to control groups during the same time periods. At the end of 6 hours rats were sacrified after blood samples were taken. Blood samples were centrifuged and plasma melatonin levels were measured by radioimmuno assayResults: When Group night sevofluran (N-S) was compared with Group night control (N-K), significant difference was found on melatonin levels (p=0,002). When plasma melatonin levels compared between Group day sevoflurane (D-S) and Group day control (N-K) , melatonin level of Group Day sevofluran was found highly significant (p=0,002). Similarly, when plasma melatonin levels compared between (N-K) and (D-K), melatonin level of N-K was found significantly high (p=0,002).Conclusion: In this study, it has been ascertained that 2.6% sevoflurane administered for six hours during the day and night period increased melatonin levels significantly in 15 days old rats.Keywords: Sevoflurane, rat, melatonin