The comparative evaluation of the effects of cerebroventricular administration of albumin, mannitol, hypertonic sodium chloride, glycerine and dextrane on experimental brain edema

Scope: The aim of this study is the comparative evaluation of some hyperoncotic agents which are administered by stereotactic cerebroventricular means after experimental brain edema.Material and Method: A total of six groups of rat ? five experimental and one control ? in similar conditions were used in the study. Standard brain trauma was obtained by means of weight drop method. In therapy groups, 2 microliters of therapeutic agent was administered 6, 12, and 24 hours after neurotrauma by cerebroventricular stereotactic route. The rats were sacrificed after 48 hours and brain tissue was extracted without extra damage. GSH, NO, MDA, TNF-alpha, and IL-1-beta analyses were performed on traumatic left hemispheres.Results: GSH levels on all therapy groups excluding the dextrane group showed a statistically significant increase compared to the control group. MDA and NO levels had different ratios of decrease which showed a trend but no statistical significance. IL-1-beta had a significant decrease on therapy groups, but TNF-alpha analysis revealed no difference among control and treatment.Conclusion: The results of the study showed that brain edema and secondary brain injury due to oxidative stres may be decreased by the use of some hyperoncotic/hyperosmotic agents in experimental basis. Further studies with these agents may be promising.Key Words: Head trauma, Albumin, Mannitol, NaCl, Glycerine, Dextrane.