Comparison of the effects between meperidine and deksketoprofen in renal colic

Selection of appropriate and effective analgesic for the patients admitted to emergency services with renal colicky pain is very important. In this study we aimed to compare the analgesic efficacy and the effects on hemodynamic variables between meperidin and deksketoprofen in patients admitted to Cukurova University Medical School Emergency Department. A prospective, randomized, double-blind clinical study was planned and initiated after obtaining the approval of the Ethics Committee of the Board.The patients between the ages of 18 to 70 with both sexes who admitted to our emergency service and take a diagnosis of renal colic were included in our study. The patients who has non-steroidal anti-inflammatory drug allergy, received analgesic drugs in last 24 hours, with a diagnosis of peptic ulser, receiving anticoagulant therapy, has a solitary kidney, with moderate or severe hydronephrosis, serum creatinine level determined over 2 milligrams per deciliter, pregnant, breast-feeding were exluded from study. Total 52 patients were enrolled.Vital signs, labaratory tests and ultrasound findings were compared between meperidine and deksketoprofen drug administration groups. There was no significant statistical differences between the systolic and diastolic blood pressures, pulse rates, respiration rates, blood urea nitrogen, creatinin, white blood cell count, hematuria, leucocyturia values, the detection rate of nefrolithiazis and mild hydronephrosis.When we look at changes in vital signs before and 30 minutes after application of analgesic drugs, we see that both two analgesic groups made statistically significant decreases in pulse rate, breathing rate, systolic and diastolic blood pressure. Although the reduction in the meperidine group is a little bit more than deksketoprofen, there was no significant statistically differences.According to our study, an opiate drug meperidine and the non-steroidal anti-inflammatory drug deksketoprofen which is used to treat renal colic has similar analgesic efficacy. Meperidin and deksketoprofen has a similar pattern of decline in Visual Analog Scale and Renal Colic Symptom Score despite the differences between initial Visual Analog Scale scores of this two analgesic drug groups.