The significance of serum SAA, CRD and C5a levels in the diagnosis and management of acute renal allograft rejection

ABSTRACT THE SIGNIFICANCE OF SERUM SAA, CRP AND C5A LEVELS IN THE DIAGNOSIS AND MANAGEMENT OF ACUTE RENAL ALLOGRAFT REJECTION Serum SAA, CRP and C5a levels of renal transplant patients with normal functioning and acute rejection occured kidneys were compared in this study. To interpret the significance of their levels in the early diagnosis and follow-up of acute rejection has been aimed. Twenty-four patients who underwent renal transplantation at the University of Çukurova Transplantation Unit between November 2001 and May 2003 were included in the study. Twenty-one healthy people were taken as control group. In 5 of the 24 patients who underwent renal transplantation acute rejection occured. Serum SAA, CRP and C5a levels of all patients have been determined and the results have been evaluated. The outcomes indicated that serum SAA and CRP levels increased 1 to 2 days prior to acute rejection and this is statistically significant (p<0,001). However, there was no difference in the serum levels ofC5a(p>0,05). It can be concluded that the use of serial measurements of serum SAA and CRP levels is a valuable and easy method in the early diagnosis and management of acute allograft rejection. Key words: CRP, SAA, C5a, acute rejection, renal transplantation V