The evalution of the effect of melatonin on methylglyoxal-induced endothelial dysfuntion in rats
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Abstract (EN)
Results: Phe- and KCl-induced contractile responses in the thoracic aorta were not significantly decreased in MGO-administered group, compared to controls. MGO administrartion significantly inhibited the relaxation response induced by ACh, while the relaxation to SNP was not significantly altered. In addition, eNOS and p-eNOS expressions decreased significantly in arteries obtained from MGO administered rats. The impaired endothelium-dependent vasodilatation as well as decreased expressions of eNOS and p-eNOS in vessels obtained from MGO group rats were significantly improved by melatonin treatment. Key words: Endothelial dysfunction, methylglyoxal, melatonin
Author
Ayşe Gül Gönen
How to Cite
Ayşe Gül Gönen (Master Thesis). The evalution of the effect of melatonin on methylglyoxal-induced endothelial dysfuntion in rats, 2020, Akdeniz University.
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