The investigation of urotensin 2 level oxi̇dati̇ve metabolism and oxidative dna damage in schizoaffective patients in symptomatic remission and not in symptomatic remission

Aim: In this study we aimed to investigate oxidative metabolism, oxidative DNA damage and level of Urotensin 2 in schizoaffective patients according to the patients' conditions whether they are in symptomatic remission or not. Method: 54 patients with schizoaffective disorder according to DSM-IV-TR and 27 healthy volunteers were included. 27 of these schizoaffective disorder patients were in symptomatic remission and 27 of them were not. Serum 8-hydroxideoxiguanosine (8-OHdG), Total Antioxidant Level (TAS), Total Oxidant Level (TOS), Urotensin 2 Level (UTS-2) evaluation and Oxidative Stress Index (OSİ) calculation were conducted in Gaziantep University Biochemical Laboratory. Results: There were no significant differences between patient and control groups in terms of TOS, OSİ and 8-OHdG levels. TAS and UTS-2 levels of schizoaffective disorder patients were found to be significant lower than controls. In addition, TAS and UTS-2 levels were found to be lower in schizoaffective disorder patients who were both in symptomatic remission and not in symptomatic remission than control group. There were no significant differences between patients in symptomatic remission and not in symptomatic remission in terms of TOS, OSİ, TAS, UTS-2 and 8-OHdG levels. Conclusion: There is a defect in the antioxidant systems in shizoaffective disorder patients. UTS-2 which is important in immunological, endocrinological and oxidative systems and deficiency in antioxidant system might take a place in the ethyopatogenesis of schizoaffective disorder. Key words: Schizoaffective disorder, Urotensin 2, oxidative DNA damage, Oxidative stress.