Nutrition in patients with sepsis molecular levelinvestigation

Sepsis infection-induced physiological, pathological, biochemical abnormalities is a serious public health problem. True incidence not known, but one of the leading causes of worldwide mortality It is estimated to be (1). Circulatory septic shock mortality risk is much higher than sepsis alone. system disorder, accompanied by cellular and metabolic abnormalities, mean artery vasopressors needed to maintain the pressure of 65 mmHg and above; 2 mmol / L (> 18 mg / dL) above the serum lactate level in the absence of hypovolemia is defined by the table. In the presence of these two findings, the mortality risk is more than 40%. is high (1). Sepsis and septic shock have high mortality rates ranging from 20% to 50% even today rates. Although it is necessary to determine the active microorganism culture tests are time consuming and always useful because of their low sensitivity can not be (2). SOFA and APACHE 2 scores are often used to evaluate the severity of sepsis. It is used. The use of these scoring systems is quite complex and time-consuming. Is the receiver. The collection of parameters for scoring is always possible It may not be. Therefore, to evaluate the severity of sepsis more easily There is a need for a biomarker that can be measured (2). Increased malnutrition, especially in sepsis, in ICU patients morbidity and mortality and nutritional Support is extremely important. Sepsis, proinflammatory metabolic response, increased energy consumption, with accelerated catabolism and hyperdynamic circulatory changes Characterized. In this context, decrease in lean body mass, organ dysfunction and immune function occurs, which protein malnutrition, increase in infectious morbidity, artificial 2nd respiratory addiction, intensive care and increased hospital stay and mortality situations such as increase. In this study, 1,3mg / kg / day protein supplementation in sepsis patients 2mg / kg / day dose of protein supplementation in patients fed with inflammatory and The aim of this study was to compare the level of antiinflammatory molecules.