The relationship between the levels of S-100 protein and neuron specific enolase and neurological deficit and prognosis in serebrovascular diseases.

Stroke (Ictus) is defined being influenced of a part of brain result of ischemia or hemorrhagetemporarly or permanently. And one or more blood vessels which connect with brain aredefined as primer patology. Among the all ictuses (stroke) the brain infarct is %70-80 , intra? cerebral Hemorrhage is % 7-15 and subarachnoin hemorrhage is 2-8 stroke is not only seenin developed countries but alsa it is the most important reason of mortality or morbidinty.The modern menitorins techniques (like CT,MRG) help clinicians to identify the location andthe volume of infarct and hemorrhage however repeating them for monitoring is impracticalln brain damages, S100 is protein, NSE , İL-6 , myelin basic protein and the measuretechnique of blood level help us/show us opportunity the more testing with the less risk andbrain damages and to diagnose and early therapy.S100 is a connective acidity protein. Protein consists of two units S100 ßß ewists inastrocyte and shwann cells while high concentrations. NSE 2 is an enzyme which translatesthe phosphoglycerat to phosphoenol pyruvate. Dimeric ?? form is specific for gliyal cells.IL-6 is a cytokine has many different functions enable to growth and differentations ofdifferent tissues. ln many studies shown that İL-6 is increasing in the location of loss cel.Recently the relations between increasing inleve serum s100 protein, NSE an IL-6 anddifferent acute brain damages have been revealed. The testing of NSE and S100 proteins giveimportant knowledges in the estimate of establish the illness oragnosis, the statement ofdamage , the dete minate of therapy,toevalvate the therapy. ln our study,we have taken 50patients with ischemic and 25 patients with hemarogic. The patients participating in the studywere measured serum S100 protein, NSE and İL-6 on admission (within 24 hours) on secondand third and tenth days. But the control group was measured only one time. Patients withischemic were grouped according to lesion types categorizated by bamford and his friends .patients with ischemic were evaluated LAC1 n=14 (%28),TACI n=3(%6) and POCS n=3(%6)Patients with hemarogic were evaluated supratentorial n:17, and in fratentorial n=8The Immunoasay analysis was used for S100 Protein and NSE .The ECLIA analysis wasused form odular analytics E170.In all measured days NSE ,S100 protein and IL-6 have maunhy increaced in patients withischemic and hemorogic to control group. On the patients with ischemic, the highest S100level was measured on secand and third days. Although (the patients with hemorogic) S100protein level was measured in all days and found the protein level high, the highest level wasmeasured on third day.In our study the highest S100 level was found in TACI group In thepatients with hemorogic stroke were found high S100 level on the measuremeıt days, thehighest level was revealed in supramentorial grouphad It was found that the patients withischemic (ex) had much more S100 protein NSE and IL-6 than discharged patients withischemic. In our study the highest S100 protein and levels were seen over is years.Theminimum level is measured between 0-1 and 2-7 with NIH scala. We found the highest NSE,S100 protein and IL-6 levels among the bad prognosis patients. The frequency variations ofS100 protein level show a good correlation with clinical results.Especially,when neurologic deficit and cerebral damage are increasing S100 and NSE levelsare dearly inreasing too. We found also hing S100 protein, NSE and İL-6 level with badneurologic deficit and eks besides, the increation in S100 on the patients with ischemic lesionand hemorrhage is more clear than. NSE.Consequentlu there are important markers to estimate neurogic deficit, to therapy, to followthe course of disease and to prognose when the patients ischemic and hemorogic. BesidesS100 protein is more specific to SSS than NSE.