The predi̇cti̇ve value of plasma TGF-b levels i̇n i̇n-stent restenosi̇s

Introduction: Coronary artery disease (CAD) is the leading cause of mortality and morbidity in Turkey as well as the other developed countries. Percutaneous coronary intervention(PCI) is the most common revascularization strategy in management of CAD. Earlier, PTCA is the only revascularization strategy; however, today over %80 of the patients has undergone PCI. Restenosis rate six month after succesfull PTCA is reported as %32-57 (6). Although restenosis rates compared to PTCA has been significantly decreased after PCI has become prevalent, in-stent restenosis(ISR) has been encountered about %10-40 of the cases (8,9). ISR is one of the most important cause of both early and late morbidity in CAD. If predicted, ISR could have very important potential to decrease the mortality and morbidity rates and provide cost-effectivity and even in picking up the treatment strategy. Objectives: We planned to investigate if there is a corelation between plasma TGF- β levels and ISR and whether or not this molecule could predict future ISR. Method: 82 patients who has prior PCI history in Düzce University Medicine Faculty Hospital and is scheduled for coronary angiography for any reason is included the study. ISR is defined as >%50 narroing inside the stent. Plasma TGF- β levels are studied in all patients. Findings: We found no significant corelation between ISR and TGF- β levels (p=0,754). In multivariate regression analysis there is negative corelation between ISR and target vessel diameter, and positive corelation between ISR and RCA lesions. Conclusion: As far as we know there is no study investigating the corelation between ISR and TGF- β levels. This study has shown that there is no quality of TGF- β in predicting ISR. It is clear that this study should be redisigned with larger cohort and conducted as a prospective study with other molecules assumed to have predictive values of ISR as well as TGF- β if possible . Key words: in-stent restenosis, TGF- β, coronary artery disease, percutaneous coronary implantation