The levels of plasma endothelin-1, platelet activating factor acetyl hydrolase, transforming growth factor beta-1 and serviceable of these markers at differential diagnosis in newborn infants diagnosis with respiratory distress

2. ABSTRACTTHE LEVELS OF PLASMA ENDOTHELIN -1, PLATELETACTIVATING FACTOR ACETYL HYDROLASE, TRANSFORMINGGROWTH FACTOR BETA-1 AND SERVICEABLE OF THESE MARKERSAT DIFFERENTIAL DIAGNOSIS IN NEWBORN INFANTS DIAGNOSISWITH RESPIRATORY DISTRESSThe most important reasons for the extension of hospital period in prematurebirths, are the problems that are related to respiratory system. Respiratory distresssyndrome type 1, respiratory distress syndrome type 2, meconium aspirationsyndrome are the most common reasons of respiratory distress, while early diagnoseof the disease and appropriate treatment started on time, are also important forincreasing the life quality and extending the lifetime period.The increased levels of endothelin-1, which is responsible forbronchoconstruction and vasoconstruction in many organ insufficiencies are relatedto the bed prognose. Despite the fact that transforming growth factor beta has anrectifier impact on inflamation and increaser impact on tissue recovery; its extremeaccumulation leads to the extension of inflamation and fibriosis. Another cytokineplatelet activating factor, causes vasoactive impact on the lungs and inducesbronchoconstruction. Platelet activating factor acetylhydrolases, is the enzyme,which counteracts PAF by decomposing it.In this study, the assessment of signifance for the consideration of serumendothelin-1, transforming growth factor beta-1 and platelet activating factoracetylhydrolases levels in the distinctive diagnose, follow-up of the newborns withrespiratory distress and determination of prognose, are aimed.3The babies, who were taken to newborn intensive care unit, have beenincluded within the scope of this study. A study group of 100 newborns; 62 of whichwith RDS type 1 diagnose, 24 of which had RDS type 2 diagnose, and 14 of whichhad meconium aspiration diagnose within one year, has been established. Also, acontrol group of 20 premature and mature babies without any problem has beenestablished. It has been found out that endothelin-1, transforming growth factor betaand platelet activating factor acetylhydrolase did not differentiate in the controlgroup of premature and mature babies; but endothelin-1 and transforming growthfactor beta was increased in RDS type 1 and RDS type 2, while they were increasedmost in meconium aspiration. The increase in the level of platelet activating factoracetylhidrolases has been determined in only meconium aspiration. It has beenobserved that, endothelin-1 checks at the early hours were rather useful for thedetermination of prognose and endotelin-1 checks during the further days were ratherexpressive for the indication of the recovery. It has been concluded that the levels oftransforming growth factor beta and platelet activating factor acetylhydrolases,which have been checked at early hours, were not expressive for the determination ofprognose.Key Words: Respiratory distress syndrome type 1, respiratory distresssyndrome type 2, meconium aspiration syndrome endothelin-1, transforming growthfaktör beta, platelet activating factor acetylhydrolases, newborn.4