The study relation of endothelin-1 and malondialdehyde wi̇th chronic kidney disease

Chronic kidney disease is a worldwide public health problem with an increasing incidence and prevalence. A cross-control study was carried out for the estimation of endothelin-1 and MDA and some parameters in patients with chronic renal disease. The number of patients under the study were 40 patients with chronic renal disease (under hemodialysis) their ages were between 20-75 years old. The study included 40 healthy control group who haven't any disease, with the same demographic properties. The study showed that the highest mean level of endothelin-1 and MDA were found in patients with chronic renal disease as respectively (102.6±15.1 pg/ml) and (12.03±3.94 nmol/ml). The lowest mean of the two markers was in the control group as respectively (39.03±5.94 pg/ml) and (7.56±2.25nmol/ml). The current study showed that the mean age of patients enrolled in the study was 51.7 years, the highest mean of endothelin-1 in HD patients was recorded within the age group > 50 years with hypertension (P<0.05). The study showed that the highest means level of B. urea, S. creatinine and Cystatin were found in patients with chronic renal disease (156.3±22.4, 7.22±2.91 mg/dl and 12.88±2.16 mg/dl) respectively, and the lowest means of the tests above were noted in the control group with highly significant relation (P. value <0.01). The study showed a positive correlation of ET-1 and MDA with B. urea, S. creatinine and cystatin c. The study showed a significant positive correlation of MDA with ET-1 in CKD patients (r: 0.57, P<0.01).