Study of some bio chemical and oxidative strass parameters in serum of Iraqi leukemic patients

Oxidative stress occurs when free radicals and reactive oxygen species exceed antioxidant systems, activating several transcription factors and affecting their transcriptional pathways. Oxidative stress affects leukemia incidence, progression, and therapy. This research examined leukemia-related oxidative, physiological, and biochemical factors. The study included 200 Iraqis, including 150 leukemia patients. 50 healthy individuals aged 6–68 were the control group. Medical patient got six milliliters of blood collected from Al-Yarmuk Teaching Hospital. Oxidative parameters in both patient and healthy groups showed that MDA increased significantly in the patient group (278.6) Pg/ml compared to control, TAC did not differ significantly, and FRAP decreased significantly in leukemia patients (18.49) Pg/ml simultaneously glucose levels, albumin and protein carbonyl increased in all leukemia patients, although creatin decreased (18.36) Pg/ml compared to the control group (27.06). Lipid profile test showed that leukemia patients had higher cholesterol, triglycerides, and VLDL (239.7, 40.53, and 189.2) than controls (170.8, 20.68, and 104.9) but no significant differences in HDL or LDL