Investigation of the synthesis of N-substituted pyrrole derivatives

Pyrrole and its derivatives are the heterocyclic compounds which not only are found in structure of both some bioactive drugs and some natural compounds such as haem, chlorophyll, B12 vitamin; but also show some important pharmacological properties such as antibacterial, antiviral, antitumor etc.In this research work, N-substituted pyrrole derivatives were synthesized by Paal-Knorr condensation of 2,5-hexanedione with a variety of different primary amines under subcritical conditions in which water acts as a catalyst and solvent for organics. As a result of the experiments, a simple, clean, and environmentally friendly process is developed for pyrrole synthesis and this process can be easily applied for synthesis of different pyrrole compounds with a high yield.