Synthesis of pd nanoparticles supported on carboxylated graphene oxide for electroanalytical determination of paracetamol in human serum

The study includes a novel paracetamol (PA) sensor depending on Pd nanoparticles (PdNPs) deposited on carboxylated graphene oxide (GO-COOH) modified glassy carbon electrode (GCE). Nafion (Nf) was used as a protective membrane. The as prepared composites were characterized utilizing high resolution transmission electron microscopy (HRTEM), X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), and Fourier transform infrared spectroscopy (FTIR). The experimental results illustrated that Nf/GO-COOPd nanocomposite exhibited excellent electro catalytic response to the oxidation of PA. The linear range of the sensor was found to be 0.04-800 µM for PA with limit of detection (LOD) of 0.012 µM and sensitivity of 232.89 µA mM-1 cm-2. By considering the excellent electrocatalytic performance of Nf/GO-COOPd composite such as a wide linear range, lower detection, better selectivity, repeatability, reproducibility, and storage stability, the GO-COOH support is a promising support for the modification of electrode material in electrochemical sensor and biosensor field.