The correlation between biochemical bone markers, bone dansitometry and iron accumulationn in patients with thalassemia major, intermedia and sickle cell disease

Objective: The purpose of this study, to determine the relationship between bone dansitometry and biochemical bone markers in thallasemia major, intermedia and sickle cell anemia patients who have been followed by C.U.T.F Hematology Clinic Materials and methods: We studied prospectively 102 thallasemia major, intermedia and sickle cell anemia patients who have been followed by C.U.T.F Hematology Clinic, in this study. As a biochemical bone marker we tested calcium , phosphorus, alcalene phosphatase ,parathormon ,ferritin and D vitamine values. This biochemical bone marker values were compared with bone dansitometry results. SPSS 20.0( SPSS Inc.Chicago,III, USA) packet programme was used for evaluating the results. Findings: Osteoporosis was found frequently at patients who have hemoglobinopathy. Also D vitamine values were obtained significantly lower levels at patients. It is significantly obtained that there is a relationship between low vitamin D, high ferritin levels and DEXA score decreasing. Especially, severe D vitamine deficincy with DEXA score decreasing is more evident. Result: Researching with bone dansitometry and biochemical bone markers at younger ages is important between thallasemia major, intermedia and sickle cell anemia patients. Replacing sufficient D vitamine and maintaining ferritin levels to normal range will reduce the morbidity of osteoporosis.