Retrospective analysis of demographic data and clinical properties of stomach cancer patients whom metastatic at time of diagnosis

Purpose:. On this study; It was aimed to examine the demographic properties and clinical features of stomach cancer patients who was metastatic at time of diagnosis retrospectively. Material and Method: In this study, the data of patients who were followed up with the diagnosis of stomach cancer in Inonu University Medical Faculty Medical Oncology Department between 01.01.2010-31.12.2019 were examined. Patients diagnosed with lymphoma, gastrointestinal stromal tumor and neuroendocrine tumor (NET) were excluded from the study. Totally 154 patients who were metastatic at the time of diagnosis and whose pathology preparations were available in our center were included in the study. Age, gender, first place of metastasis, histological type, tumor stage, lymphovascular and perineural invasion presence, number of invaded lymph nodes , pathological type, degree of differentiation, cerb B2 positivity, presence of brain metastasis, hemogram and biochemistry values at the time of diagnosis and the treatment methods applied were evaluated in 154 patients included in the study. Results and Conclusion: Totally 74.7% (n = 115) of the patients were male and 25.3% (n = 39) were female. The median age of the patients was 68 (min: 18, max: 97). The median age of men and women was similar (67 vs 69 p = 0.688). The mean hemoglobin value was 11.6 g/dl, the average LDH value was 236.5 ıu/l, and the mean albumin value was 3.2 g/dl at time of diagnosis. The most common tumor location was at the proximal region (57.8%). The most common histological subtype was intestinal (59.5%). Totally 42.8% (n = 27) of the cases were grade 4, 36.6% (n = 23) of grade 3. Totally 42.5% of the cases were low, 23.4% were moderate, 23% were well differentiated. Cerb B2 receptor positivity was present in 4.3% of the cases. 95% of cases had lymphovascular and 88% had perineural invasion. The first place of metastasis is liver in 63.6% of cases, peritoneum in 24.7%, lung in 5.8%, ovaries in 2.6%, bone in 1.9%, diaphragm in 1.3% of cases. The median survival time for all cases was calculated as 8 months and median follow-up time was 8.1 months. With low serum albumin level (<3.5 mg / dl), high serum LDH level (> 250 ıu/l) and anemia (Hb <10 mg / dl), overall survival (OS) decreases statistically significantly, p values are 0.01, 0.01, respectively. In addition, progression-free survival (PFS) decreases statistically significantly with low albumin level (<3.5 mg/dl) and high serum LDH level (> 250 µl/l), p values are 0.05 and 0.03, respectively. There was no significant difference with anemia (p=0.06). Keywords: Metastatic gastric cancer, demographic data, Cerb B2