Production of portable and low cost quartz tuning fork drive based prototype and construction as immunosensor

Living things perceive changes in the environment through their sensory organs and shape their lives according to these changes. The use of biosensor structuring strategies in the diagnosis of various diseases by imitating nature is an approach to make sense of changes in the environment, just like the sense organs. In this thesis, first of all, it is to define the quartz tuning fork (QTF) driver, which is called the first generation and has a patent value, and to introduce the device called the second generation with the development of this device within the scope of the TÜBİTAK supported project numbered 118S614. The main scope of the thesis is to investigate whether two selected analytes (transferrin and circulating tumor cell in blood) can be diagnosed with a new approach, a quartz tuning fork-based mass-sensitive immunosensor configuration. These two analytes are specially selected. The reason for this choice is that transferrin, the first of the two analytes, is an important biomarker molecule in diagnosing cerebrospinal fluid leaks in cases where the history of the disease is frequently confused with influenza and imaging methods are insufficient. On the other hand, the other analyte selected, the circulating tumor cell in the blood, is a very important biomarker molecule that enables cancer to be diagnosed at an early stage. QTF mass sensitive immunosensor was configured for the aforementioned purposes and important data were obtained (R2=0,9686).