Tavşanlarda spinal kord iskemi ve reperfüzyonu üzerine renin inhibitörü aliskrenin etkileri

Introduction and Objective: The most important neurological complications experienced in TAA surgery are paraplegia and paraparesis which are the results of spinal cord ischemia. Despite of there are lots of preventive procedures developed to reduce these complications, unfortunately none of these methods is enough itself. To protect the ischemia-reperfusion injury of the spinal cord while cross clamping, increasing the ischemic tolerance of spinal cord by pharmacological agents is one of the methods that considered and tried. Considering lots of pharmaceutical substance have been tried in this aspect, none of these approved as a complete success by the authority.The aim of this study is to evaluate the usability of Aliskiren as an ischemia reperfusion injury protector..Material and Method: We used 17 New Zealand Rabbits weighted betwee1500-2500 grams in this study. Ischemia formed with buldog clamps applied on Aorta justabove the Renal Arteries for 30 minutes. The test subjects divided three groups:Sham group (n:3), Control group (n:7), Aliskiren group (n:7).After neurologic evaluation, the subjects sacrified with high doses of ketamine+xylazine and their thoracolomber level spinal cords extracted to be examined histopathologically with light microscope. This histopathological evaluation focused on neurodegenerational determinants espicially nucleus, organel level damage and edema, myelined neural fibers structural degeneration, axoneme structure and pericapillary edema.Findings: There is a statically meaningful difference between neurologicalevaluation of the groups (p<0.05) and histopathological evaluation (p<0.001). As aresult of this research; Aliskiren found to reduce the ischemia reperfusiontissue edema. Aliskiren decrease the ischemia reperfusion injury