Comparision of HSCRP, CEA WBC levels of patients with bipolar i manic episode with adequate response to treatment, i̇nadequate response to treatment and healthy control group

Aim: Our aim in this study is to investigate the relationship between serum hsCRP, CEA, WBC, lymphocyte levels and treatment response with or without adequate response in patients with bipolar disorder who were followed up at the outpatient clinic or inpatient clinic for disease pathology. Material and Method: Dicle University Medical Faculty Hospital Psychiatry Department 60 patients who were diagnosed and treated for bipolar disorder I according to DSM-5 criteria between the ages of 18-65 between May 2015 and August 2016 were included in the study after receiving their informed consent from 30 healthy control groups. Patients were evaluated for acute mania at least 6-8 weeks of treatment. At the time of the treatment, at least one of the drugs he had recently received was noted as a mood stabilizer and at least one of them was an antipsychotic drug. 3 groups were formed. Group 1: 30 healthy volunteers (control group), Group 2: 30 patients who responded adequately to manic epilepsy treatment, and Group 3: 30 patients with inadequate response to manic epilepsy. The disease; Attitude Form, Sociodemographic Data Form, Young Mania Assessment Scale, Hamilton Depression Rating Scale, Hamilton Anxiety Scale, Clinical Global Impression Scale (CGI). SPSS 18. 0 statistical package program was used in the analysis of the data. Results: When the sociodemographic data of the patients were examined, it was found that there was no statistically significant difference in terms of age, gender, marital status, education, place of residence, cigarette use, and similarity in all groups (p> 0.05). It was found that the alcohol and substance use narrative was more frequent in the patients with inadequate response and statistically not significant (p>0.05). There was a statistically significant difference in working status between the groups (p<0.05). It has been determined that your function is impaired in Group 3 patients. There were no significant differences between the groups in terms of substance use history and alcohol use (p = 0.117). Smoking among the groups was significantly higher in group 3 patients (p <0.05). There was a statistically significant difference between Group 1 control group and patient groups (Group 2 and Group 3) when v compared with the mean total score of HMCS, HAMER mean total score, HADS mean total score and CGI-S mean score (p<0.05). In Group 3, the scale scores were higher. Comparisons of hsCRP, CEA, WBC, and LENFOSITE values of 3 groups of patients were found to be higher in Group 3 with hsCRP, CEA, LENFOSITE values but no significant difference (p>0,05). When the WBC values of the groups were compared, the Group 3 WBC values were higher than the other 2 groups at a statistically significant level (p<0.05). There was a significant correlation between WBC and clinical scales (p<0,05). There was a positive correlation between CEA levels and YMRS. Conclusions: According to this study, patients with bipolar disorder I may have more severe inflammation than healthy controls in patients who respond adequately to treatment of inadequately responding manic episodes and treatment. As a matter of fact, the results of our study showed that hsCRP, CEA, WBC, and Lymphocyte values were higher in Group 2 and Group 3 patients compared to the control group. However, there can be many factors that can affect the results and the findings in this study should be supported by future studies.