In patients diagnosed with recurrent bronchiolitis evaluation of serum YKL-40, periostin, neopterin levels

The wheezing is caused by the narrowing of the small airways, a scale similar to that of a thin one, often accompanied by extension in the expiration. Sweet baby; it is used for wheezing that lasts for at least one month under two years, or for children who have had three or more wheeze shots for two months and no underlying disease. The incidence of wheezing, asthma and allergic diseases is increasing day by day. The prevalence of wheezing in children under five years in developed countries was found to be 15-32%. In children with recurrent wheeze episodes were identified in terms of the duration and timing of wheezing and the ease of diagnosis and follow-up episodic wheeze and multiple trigger wheeze to be two phenotypes. The aim of this study in children with recurrent wheezing was to evaluate neopterin, YKL-40, periostin levels and to assess whether there is any difference between patients with episodic wheezing and multiple triggering wheeze. This study, between July 2016 and June 2017 Başkent University Medical Faculty Hospital, Child Health and Disease, Pediatric Emergency and Child Allergy Polyclinic were admitted to aged between 0-3 years who with at least 4 occasions whispering for a year wheezing non-attack period a total of 61 epizodic children, 51 multiple-triggering wheeze, and 56 healthy children of similar age and gender. Patients and control group received 2 ml blood samples from tubes used in routine biochemistry tests for YKL-40, Periostin, Neopterin. YKL-40, periostin and neopterin values were evaluated among the groups. All 168 patients participating in the study were from children under 3 years of age. Neopterin, YKL-40, periostin values were lower in the recurrent wheezing group than in the control group, but no statistically significant difference was found. According to Asthma Predictive Index; neopterin, periostin and YKL-40 values were not statistically different.YKL-40 and periostin values were found to be statistically lower in the wheezy children under montelukast treatment (p <0,05). There was a negative correlation between age and neopterin, periostin and YKL-40 levels (p <0.05). As a result, in our study, children who had recurring wheeze; There was no difference in periostin, YKL-40, neopterin levels according to the wheeze phenotype and Asthma Predictive Index. This is the first study of serum periostin and neopterin levels in children with recurrent wheezing in the literatüre. In this regard, there is a need for more patient numbers and extensive studies to compare with the episode.