Investigation of the frequency of polyglandular autoimmune syndrome in patients with type 1 diabetes mellitus and its relationship WİTH the prognosis and complications of diabetes

Type 1 diabetes mellitus (T1DM) is one of the most common chronic diseases that develops in childhood. One third of these patients have an autoimmune polyglandular syndrome (OPS). In this study, it was aimed to investigate the frequency of OPS accompanying T1DM and its effect on prognosis. Our study included 99 patients who applied to the endocrine outpatient clinic and were followed up with the diagnosis of T1DM. Chi-square analysis (Pearson Chi-square), Kolmogorov-Smirnov test, Student's t-test, Mann Whitney-U test, Spearman Correlation test and Kruskal Wallis test were used in the analysis of the data. SPSS 22 package program was used in the analysis of the data. The significance value was taken as p≤ 0.05. Of the patients included in the study, 25 (25.3%) had hypothyroidism and 8 (8.1%) had celiac disease. Anti-endomysium antibodies in 9 (9.1%), islet antibodies in 50 (50.5%), anti-insulin antibodies in 22 (22.2%) patients, and anti-parietal antibodies in 26 (26.3%) patients' antibody, tissue transglutaminase IG A in 8 (8.1%), ANA in 43 (43.4%), ASMA positivity in 4 (4.0%) and OPS in 25 (25.3%) detected. It was determined that the duration of the disease of the patients with retinopathy, neuropathy and nephropathy in T1DM patients was significantly higher than the duration of the disease in those who did not. It was found that there was a positive correlation between the patients' disease year and BMI and waist circumference, and a negative correlation between the disease year and HbA1c and C peptide. It was determined that there was no significant difference between the presence of OPS in terms of presence of retinopathy, presence of neuropathy) and presence of nephropathy. In addition, there was no significant difference between the presence of OPS in terms of HbA1c value. As a result; The incidence of other autoimmune diseases has increased significantly over the years in patients with T1DM, and autoimmune diseases should be considered both at the time of diagnosis and in the following years in terms of reducing the risk of complications in the follow-up of diabetic patients, a good prognosis, good clinical development and early diagnosis. Key words: Type 1 diabetes mellitus, Autoimmune polyglandular syndrome, Prognosis