Synthesis of new 2,6-disubstituted -3(2h)-pyridazinone derivatives and research of their biological activity
2012
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Advisor: Prof. Dr. M. Fethi Şahin
Abstract (EN)
Inthisstudy, twelvenewcompondscarrying 4-substitutedphenylpiperazinoethyl structureat position 2 of 6-(4-subtitutedphenyl)pyridazine-3(2H)-one ring rstructureswereconfirmedby1H-NMR, Massandelementalanalysis. Afterthat, theiranalgesicand anti-inflammatoryactivitieswereevaluated in vivobyusingp-benzoquinon-inducedwrithing test andcarrageenan-inducedhindpawedema, respectively.Amongthesynthesizedcompounds, 6, 7, 10 and 11 haveanalgesicandanti-inflammatoryactivities.As obtainedresults, compounds10 and11werefoundtohavethehighestanalgesicandanti-inflammatoryactivitieswithoutgastriculcer in thetestedanimals.
Author
Didem Tiryaki
How to Cite
Didem Tiryaki (Master Thesis). Synthesis of new 2,6-disubstituted -3(2h)-pyridazinone derivatives and research of their biological activity, 2012, Gazi University.
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