Synthesis of novel bis imino thiazolidinone derivatives via green method

Thiazolidinones and derivatives have an important place in the area of heterocyclic compounds because of their presence in the structures of macrocyclic complex drugs, their applications in industry and usage in pharmaceutical researches due to their biological pr operties. Besides, modification of the 2 - , 3 - , 4 - or 5 - positions of thiazolidinone ring is successful to achieve synthetic products with a wide spectum pharmacological activity. In the light of literature researches made, synthesis of some new bis iminothi azolidinone derivatives that may have biological activity is aimed in this study. The study consists of two steps. In the first step, substituted thioureas which were planned to use as substrates in the principal reactions, will prepare by the reaction of aryl isothiocyanates with substituted amines. Thioureas have an important role in the synthesis of sulphur - and nitrogen - containing heterocyclic compounds due to their ability to make advanced reactions. Addition to this, thiourea derivatives have attracte d attention during the last decades due to their significant biological activities as antitubercular, antibacterial, antifungal, anti - HIV, antihypertensive as well as good anticonvulsant properties. In the second step which is the main part of the study, cyclocondensation of each of the previously prepared substitued thioureas with chloroacetic acid and hetaryl carboxaldehydes is achiev e by the technique of one - pot multicomponent reaction; and new bis imino - 4 - thiazolidinone compounds will obtain. Key words : Bis iminothiazolidinone, thiourea, multicomponent reaction