Synthesis of new heteroaromatic thiosemicarbazone compounds

Heteroaromatic compounds are cyclic organic compounds that contain heteroatoms such as nitrogen, sulfur, and oxygen in addition to carbon atoms in their structures. Thiosemicarbazones belong to the class of Schiff bases obtained by the condensation of thiosemicarbazides with aldehydes or ketones. Due to the presence of conjugated nitrogen, sulfur skeleton systems, and imine groups, heterocyclic thiosemicarbazone compounds are particularly significant in terms of their biological and pharmacological properties. In this thesis, six new heteroaromatic thiosemicarbazone compounds have been synthesized as potential antimicrobial agents. The new heteroaromatic thiosemicarbazones were obtained by the condensation reaction of 4-amino-6-chloropyrimidine-5-carbaldehyde with thiosemicarbazide and benzaldehyde derivatives (4-phenylthiosemicarbazide, thiosemicarbazide, 4-ethyl-3-thiosemicarbazide, 2-imidazolecarbaldehyde, 2-pyridinecarbaldehyde) using the template method. The structures of the synthesized new heteroaromatic thiosemicarbazones were elucidated using several spectroscopic techniques (elemental analysis, FT-IR, 1H-NMR, 13C-NMR, SEM-EDS).