Investigation of the cytotoxic and antimicrobial properties of new quinoline peptide conjugates

Cancer is one of the important health problems that cause death in Turkey and in the world. Today, many treatment methods such as radiotherapy and chemotherapy are applied in cancer patients. Quinoline and its derivatives, which are among heterocyclic compounds, have many biological species and properties for the development of drugs. Quinoline compounds have an important role in anticancer drug development as they show anticancer activity. In this study, the cytotoxic effects of seven different quinoline derivatives synthesized on lung cancer (A549) and healthy lung epithelial cell (BEAS2B), liver cancer (Hep 3B), and endothelial cell (Huvec) were determined. Different concentrations were applied and IC50 values were calculated at differnet time courses. The IC50 values of compound 2 on the A549 cell line were determined as 10.48 μg/mL, 9.738 μg/mL, and 10.14 μg/mL. IC50 values of Compound 6 on the same cell line were determined as 7.307 μg/mL, 9.888 μg/mL, 10.63 μg/mL. The cytotoxic effects of these two compounds were also observed on the BEAS2B cell line. The antimicrobial effects of the compounds were determined by the minimum inhibition concentration method on various bacteria and yeast strains. It was determined that the antimicrobial effect of the compounds on bacteria and yeast was not strong. Keywords:Quinoline-peptide conjugates, cytotoxic, antimicrobial