Assessment of β-asecretase and some parameters in type 2 diabetes mellitus

Numerous pathogenetic factors are related to diabetes and Alzheimer's disease. Adiponectin shortage is associated with chronic inflammation, oxidative stress, adiponectin deficiency, and plasma-site APP expression. The coexistence of these two diseases in many individuals could be explained by cleaving enzyme 1 activity and vascular injury. This study looked at β-site APP Cleaving enzyme 1 and various biochemical markers in diabetic type 2 individuals with and without Alzheimer's disease. The research included 90 patients. Thirty healthy control volunteers were disease-free and shared similar demographic features. The study revealed that patients with both diseases had the highest mean levels of β-secretase, while those without treatment had the lowest. The patients' mean age and weight were higher than the control group's, but the length was not significantly different. A high statistically significant of SOD, catalase, Vitamin C, uric acid, GSH, FBS, K, and Zn when compared to controls, while albumin, MDA, Insulin, and HbA1c and sodium there is a no-significantly difference. There was an association between β-secretase with SOD, Vitamin C, and MDA. While there was no association with Catalase, Albumin, Uric acid, GSH, FBS, Insulin, HbA1c Na, K, and Zn. Also indicated that decrease levels of β-asecretase with age.