Çinko nanopartiküllerin çocuklarda tonsilite neden olan bakterilerin antibiyotik direnci üzerine etkisinin incelenmesi

The greatest threat to human health is the rise of microorganisms that are resistant to antibiotics. Additionally, the ineffectiveness of the present antibiotic medication due to poor solubility, durability, and adverse effects pushed researchers to look into new, creative ways to combat such persistent germs. Therefore, there is a great demand for new antibiotic delivery techniques. Due to their advantageous physicochemical features, medication targeting efficiency, increased absorption, and biodistribution, nanotechnology has garnered great interest. In this study we aim to isolate and identify the bacteria causing tonsillitis and study the extent to which their antibiotic resistance is affected when nano-zinc oxide is added due to the activity of zinc, which acts as an antibiotic for bacteria. We also aim to identify S. pyogenes as the causative agent of acute tonsillitis in pediatric patients and interpret the most typical signs and symptoms in patients with tonsillitis caused by S. pyogenes. This study was conducted in the city of Samarra, 137 samples of children aged between 4-12 years. From 137 treated samples, 21 cultures were positive for S.pyogenes (15.33%), 29 cultures were positive for beta hemolytic streptococcus non-A (SBH non-A) (21.2%), and 87 cultures were negative (56.2%). 43 children aged 4-6 years had 9 SBHA positive cases (20.9%), 54 children aged 7-9 years had 5 positive cases (9.3%), and 7 children aged 10 to 12 years had SBHA positive cases (17.5%). S. pyogenes. is sensitive to Augmentin (amoxicillin/clavulanic acid), imipenem, ampicillin, ciprofloxacin, vancomycin and azithromycin. The optimal concentration of zinc nanoparticles at zinc oxide nanoparticles was 0.03 mg/mL, and antibiotic resistance was present. ZnO NPs have greater sensitivity in comparison to antibiotics. According to the results obtained, we concluded that ZnO NPs have good bactericidal and inhibitory activity against S. pyogenes, a bacterium that can be resistant to antibiotics and causes infections in people in all regions of the Samarra. Even at very low concentrations of NPs, when bacteria are incubated in direct contact, their growth is completely inhibited, demonstrating their bactericidal activity. The low toxicity of ZnO NPs, on the other hand, must be assured in future studies.