Clinical and physiological parameter changes for liver cirrhosis and renal insufficiency in patients with major thalassemia

In this study, the most common hereditary blood illness is thalassemia, which is produced by mutations that reduce globin chain production. Functional problems and tissue damage in individuals with β-thalassemia major are caused by iron excess and associated organ deposition. The purpose of this study was to see if individuals with significant thalassemia had liver cirrhosis and renal failure, both of which are important factors in predicting and preventing end-stage tissue failure and death in people with thalassemia major. The participants in the study were (80) thalassemia patients (males and females) and (40) healthy people. As a comparison group Significant differences in AST, ALT (p<0.000), and (p<0.000) were discovered. When compared to the control groups, albumin and bilirubin exhibited no statistically significant changes (p<0.306) and (p<0.794), respectively. Urea, creatinine, uric acid, LDH, and ALP had significant differences from control groups"(p<0.000), (p<0.000), (p<0.000), (p<0.000), (p<0.000), and (p<0.000)"respectively. Keywords: Major thalassemia, Blood group, LDH, Liver, Kidney