Investigation of healing effects of Arum rupicola Boiss. Var.virescens (Stapf.) P.C. Boyce plant soiled (leaf, body) extracts on experimentally diabetic induced rats

In this study, the healing effects of extract of plant above ground (leaf, body) of Arum rupicola on diabetes were investigated in experimental diabetic rats with streptozotocin (STZ). During the experiment (25 days), blood glucose of rats was measured every five days and the body weights were recorded. At the end of experiment, in blood taken from rat, the levels of AST, ALT, LDH, blood glucose, lipid profile (TG, TC, LDL-C and HDL-C), creatinine, urea, proinsulin c-peptide, insulin and HbA1c levels were measured. Activities of CAT, SOD, GSH-Px, GST, GR, GSH, MDA, α-glycosidase and GSH, MDA levels were determined in samples taken from erythrocytes, brain, kidney, liver and small intestine tissue. According to the results, difference between first and final body weight was found significant (P≤0.05) in all diabetic groups. AST, ALT, LDH, α-glucosidase activities and blood glucose, HbA1c, urea, creatinine, TC, TG and LDL-c levels increased in the DK group compared to the NK group. These parameters decreased in the extract groups compared to the DK group (P≤0.05). The changes in insulin levels were significant in extract groups compared to the DK group (P≤0.05). Fluctuations in SOD, CAT, GSH-px, GST, GR, GSH and MDA levels were observed. However, it was observed that increasing or decreasing levels in the DK group compared to the NK group were approached to the NK group levels in the extract groups. In conclusion, it can be stated that Arum rupicola has the potential to provide protection due to its antidiabetic, antilipidemic and antioxidative properties against the damage caused by diabetes-induced oxidative stress.