On the inflammatuary effects of using single and double reservoir oxygenator during extracorporeal cırculatıon on inflammatuary response

Extracorporeal circulation is one of the most important invention of modern medicine which induce open heart surgery possible. In extracorporeal circulation blood and ingredients of blood contact with given solution and artificial surfaces. After extracorporeal circulation, coagulapathies and important pathological changes in cardiac, pulmonary, renal and cerebral functions. Also systemic diferentiations as fever, increased capillary permeability, increased interstitial fluid collection and leucocytosis reported.In this study by using two different oxigenarators, we tried to search their effects on citokins, complement, CRP and WBC levels.We studied on 24 patients who undergoing open heart surgery by CPB at Abant İzzet Baysal University, Faculty of Medicine, Department of Cardiovascular Surgery, between Apr 2010-Oct 2010. Patients divided into two groups; Studied group (single reservoir oxigenarator) and Control group (double reservoir oxigenarator). Blood samples for citokins (TNF alfa, İl6, İl8, İl10) ?(ELISA Study) complement (C3, C4)- (ABBOTT C8000), CRP- (NEFELOMETRİC) and WBC (CBC) ? (ABBOTT CELL- DYN) were obtained from radial arteriel line:(1) after intravenous heparin (3mg/kg) administration before CPB(2) 6 h. after CPB(3) 24 h. after CPBIn our study we didn?t find statistically important difference between single reservoir and double reservoir groups according to age, sex, height,body weight, DM and HT.1-C3, C4, CRP, İl6, İl8, İl10, TNF?, WBC:Pre, Post 6. and 24. h, the results were not include important difference for both reservoir groups.Key Words: : Single reservoir oxigenator, double reservoir oxigenator, citokin, complement, İl6, İl8, İl10, CRP, CPB, TNF?, WBC