In accordance with the results of the apoptosis and inflammatory effects on the hepatoma cells hep3b cynarin and inuline of polyphenols of artichoke plant would be studied

Nutrition is the most important part in every era of our lives from mother's womb till death. Eating healthy and regularly reduces the chance of heart-vain problems, diabetes, obesity, cancer etc. and in treatment it plays a significant role in vitamin insufficiency and prevent nutrition problems like protein-energy malnutrition. At the same time, adequate and balanced nutrition ensure sufficient take of the nutritional elements and other bioactive materials and helps splitting in balance the nutritional elements to the meals. Polyphenols which are found in large amount in fruits and vegetables, health benefits were discovered by 'in vitro' researches and ignored the components metabolically transformations and bio-efficiency in humans. These components which contain anti-carcinogenic and other beneficial properties are called 'organic antioxidants'. The main reason for Polyphenols protection effects is having antioxidant activities. Therefor with the creation of free radicals and determining the capacity of antioxidants, avoiding and curing the diseases in question would be easier. But in some cases, the available antioxidant defense system is not enough to prevent all the free radicals and a case that is called oxidative stress, is formed. Reactive oxygen types give assignment to an instrument in cancers formation and responsible in mutagenesis, carcinogenesis and scheduled cell deformation (apoptosis). They show close relations with apoptosis, oncogenes and cell cycle. So presenting the apoptotic paths will lead to polyphenols which by using, it would open up very important ways for research of interaction of cell cycles. Our study emphasis on Cynarin and Inuline effect mechanisms of artichoke plants (Cynara Scolymus) polyphenols in Hep3B cell strains apoptosis and inflammatory states. Researches include caspase-3, Smac-Diablo, Apaf-I and cytochrome c level from apoptotic identifier, IL-1β, IL-6 and TNF-α level from inflammation cytokines.