Comparison of level of Adrenomedullin and Calcitonin gene-related peptide ?CGRP? between Tension type headache, fibromyalgia and control group

Tension-type headache (TTH) and fibromyalgia syndrome (FMS) are pain syndroms, of that etiologies are unknown. In both situations clinical, therapautical and pathophysiological properties are similar. Adrenomedullin (AM) and calcitonin gene-related peptide (CGRP) are two peptids that use the same reseptor. CGRP is thougt to have role in migraine pathogenesis. In this study it?s aimed to research whether AM and CGRP has a role in TTH and fibromyalgia pathogenesis.Thirty-five TTH, 33 FMS patients that addmitted to our outpatient clinic and 31 healty people were icluded into the study. Complete blood count, sedimantion, CRP and other rutine biochemical tests were applied. 10 ml venous blood sample were taken from patients and control groups, the samples were seperated apropriately and kept at -20°C plasma until AM and CGRP levels were measured.Plasma AM levels in TTH, FMS and control subjects were (121.23), (119.09) and (126.78) pg/ml, respectively. AM levels didn?t reveal significant differences between TTH, FMS and control groups (p>0.05).Plasma CGRP levels in TTH, fibromyalgia and control subjects were (170.42), (162.61) and (139.32) pg/ml respectively. CGRP levels were found to be significantly higher in TTH patients when compared with the control groups (p=0.025). There was not significant difference between the FMS and control groups (p>0.05).These results indicate that CGRP may have a role in TTH pathogenesis.Key Words: Tension-type headache, Fibromyalgia, Adrenomedullin, Calcitonin gene-related peptide